Anti-CIP2A Polyclonal Antibody
應用 WB
稀釋比例WB 1:500-2000.
交叉反應Human

產品型號：K106617P

更新時間：2022-08-15

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Anti-CIP2A Polyclonal Antibody

英文名稱	Anti-CIP2A Polyclonal Antibody
宿主	Rabbit
別名	CIP2A;KIAA1524;Protein CIP2A;p90
應用	WB
稀釋比例	WB 1:500-2000.
交叉反應	Human
蛋白分子量	102kd
Gene ID	57650
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	Recombinant protein of human CIP2A
性狀	液體
Public Immunogen Range	Recombinant protein of human CIP2A
Subcellular Locations	Cytoplasm Cell membrane
Swiss Prot	Q8TCG1
克隆類型	Polyclonal Antibody
背景資料	Cancerous inhibitor of protein phosphatase 2A (CIP2A), also designated p90 autoantigen or KIAA1524, is a single-pass membrane protein that exhibits oncogenic activity. CIP2A is known to inhibit PP2A (protein phosphatase 2A) dephosphorylation of c-Myc, thereby stabilizing c-Myc (an oncogenic transcription factor) and promoting tumor formation and malignant cell growth. PP2A is a trimeric protein complex consisting of three subunits: a scaffold subunit, a catalytic subunit and a regulatory subunit. CIP2A specifically interacts with the catalytic subunit of PP2A to inhibit its activity. Inhibition of PP2A activity is a crucial step allowing for the progression of human cell transformation. Further supporting its role as an oncoprotein, CIP2A is known to be overexpressed in colon, gastric, and head and neck squamous cell carcinomas.